Clinical
Clinical analysis supports disease diagnosis, biomarker identification, and therapeutic monitoring through precise measurement of biological and chemical compounds in medical samples.
Aldosterone
Overview
Aldosterone is a steroid hormone produced by the adrenal cortex that plays a critical role in regulating sodium, potassium, and water balance within the body. Abnormal levels of aldosterone are associated with endocrine disorders such as primary aldosteronism, Addison’s disease, and hypertension. Because circulating concentrations of aldosterone are typically low and subject to biological variation, highly sensitive and specific analytical methods are required to accurately measure it in biological fluids such as plasma or serum.
Test Methods
Solutions
Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) is the preferred analytical method for the precise quantification of aldosterone due to its superior selectivity, sensitivity, and accuracy compared to immunoassay-based techniques. The LC component separates aldosterone from structurally similar steroids and matrix interferences, while the tandem mass spectrometer detects the hormone through characteristic fragmentation patterns and ion transitions. This approach allows for robust, reproducible quantification at trace levels, supporting clinical diagnostics, endocrine research, and therapeutic monitoring of adrenal disorders.
Featured LC
Discover a wide range of lab equipment from top manufacturers at SpectraLab. View all to find more LC equipment!
Featured LC-MS
Discover a wide range of lab equipment from top manufacturers at SpectraLab. View all to find more LC-MS equipment!
Insulin
Overview
Insulin is a vital peptide hormone responsible for regulating blood glucose levels by facilitating cellular glucose uptake. It plays a central role in diabetes management and therapeutic research. Due to its biological importance and structural sensitivity, insulin must be analyzed with high precision to ensure product purity, potency, and stability. Accurate quantification and characterization are critical during pharmaceutical manufacturing, formulation development, and quality control to maintain therapeutic efficacy and patient safety.
Test Methods
Solutions
High-Performance Liquid Chromatography with Ultraviolet detection (HPLC-UV) is a robust and reliable technique for the analysis of insulin in pharmaceutical preparations and biological samples. Reversed-phase HPLC using a C18 column allows efficient separation of insulin from impurities, degradation products, and formulation excipients. UV detection, typically set around 214–280 nm, enables accurate quantification based on peptide bond absorbance. HPLC-UV offers excellent reproducibility, precision, and linearity, making it a standard method for routine quality control, stability testing, and batch release in insulin production and research laboratories.
Featured HPLC-UV
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Waters HPLC system with 1525 Binary Pump, 717 Plus Autosampler, 2487 UV/Vis, 474 FLD or 2996 PDA
RefurbishedIn StockPrice:$12000 USD
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Thiamine
Overview
Thiamine (vitamin B₁) is a water-soluble vitamin essential for carbohydrate metabolism and normal nervous system function. It acts as a coenzyme in key metabolic pathways such as the Krebs cycle, and its deficiency can lead to conditions like beriberi and Wernicke-Korsakoff syndrome. Because thiamine is sensitive to light, heat, and pH changes, accurate analysis is vital for assessing its stability, bioavailability, and concentration in foods, pharmaceuticals, and nutritional supplements.
Test Methods
Solutions
High-Performance Liquid Chromatography with Ultraviolet detection (HPLC-UV) is a widely adopted method for determining thiamine content in complex matrices. After appropriate sample extraction and, if necessary, oxidation to thiochrome derivatives, separation is achieved on a reversed-phase C18 column with UV detection typically set near 254 nm or fluorescence detection for enhanced sensitivity. HPLC-UV provides high precision, reproducibility, and linear quantification over a wide concentration range. This technique is ideal for routine quality control and nutritional analysis, ensuring compliance with regulatory standards for vitamin content and product labeling accuracy.
Featured HPLC-UV
Discover a wide range of lab equipment from top manufacturers at SpectraLab. View all to find more HPLC-UV equipment!
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Waters HPLC system with 1525 Binary Pump, 717 Plus Autosampler, 2487 UV/Vis, 474 FLD or 2996 PDA
RefurbishedIn StockPrice:$12000 USD
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SpectraLab Scientific Inc
Established in 2003,
SpectraLab Scientific is a global leader of Refurbished analytical equipment. We specialize in reconditioning equipment, integrating the best available technologies from leading manufacturers across the industry. We are committed to quality and service, delivering strong customer satisfaction. We stock over 10,000 pre-owned lab equipment, components, and mix-and-match parts for your systems.