AB SCIEX Triple Quad 3500 with Exion Front-end UHPLC

Complete with Peak 1024 Nitrogen Generator, Vacuum Pump and Enclosure, PC with MultiQuant and Analyst software.

The SCIEX Triple Quad 3500 LC-MS/MS system combines the ease of liquid chromatography with its inherently broad analyte applicability, with the quantitative power of triple quadrupole tandem mass spectrometry (MS/MS).

Liquid chromatography is amenable to the analysis of a wide array of analytes. In fact, many compounds that are difficult to analyze by GC such as thermally labile and chemically unstable analytes, amines, and semi-volatile compounds, are ideal candidates for LC-MS/MS. GC based assays, including GC-FID and GCMS, typically require samples to be in an organic injection solvent. This often necessitates derivatization of hydrophilic analytes to improve their volatility, ionization, or peak shape. Although usually more straightforward, HPLC-UV and HPLC-DAD assays can also involve complicated sample preparation techniques and be labor intensive depending upon the compound class. In contrast, while LC-MS/MS sample preparation methods can include solid-phase extraction or liquid-liquid extraction, they are often as simple as direct injection, dilution, or protein precipitation. By minimizing sample handling and decreasing the number of sample preparation steps, not only are areas for contamination minimized, but time is saved as well. And with today’s ultra-high performance LC systems (UHPLC), you can save even more time with ultra-fast chromatographic separations.

The sensitivity of LC-MS is indisputable. However, do you also need flexibility to handle an ever-changing queue of applications? The ExionLC system gives you more performance, more flexibility, and more options than a basic HPLC. With the ExionLC, you can build on its modular design to expand your laboratory’s range of applications and analyses. Key system features include:

• Modular design for applications flexibility
• Tray cooling preserves sample integrity
• Forced-air column oven provides stable retention times
• Large capacity solvent tray for unattended operation
• Optional accessories offer as-needed expansion

ExionLC front end includes:

• solvent tray
• Degasser
• Controller
• 2x AC Pump
• AC Column Oven
• AC Autosampler