Agilent 6430 Triple Quadrupole LC/MS System

The Agilent G6430A Triple Quadrupole LC/MS System has been specifically designed and engineered to be fully compatible with ultra high pressure liquid chromatography (UHPLC) separations and as an ideal interface for Agilent’s proprietary HPLC Chip technology. The 6430 Triple Quad is a feature-packed new addition to the Agilent triple quadrupole product family, with:

• Reliable MassHunter software
• MassHunter Optimizer for automated compound optimization
• 1 ms dwell times with no collision cell cross talk
• Dynamic MRM methods for up to 4,000 transitions
• 30 ms polarity switching for fast analyses
• Low attomole sensitivity in peptide quantitation with Agilent’s advanced HPLC-Chip Nano LC system

Controlled by proven MassHunter software, the new 6430 Triple Quad joins the Agilent 6410 Triple Quadrupole LC/MS System, an entry-level system for routine quantitative analysis, and the flagship Agilent 6460 Triple Quadrupole LC/MS System with unrivalled sensitivity powered by Agilent Jet Stream technology, to create a powerful suite of products to meet the quantitation demands of any application or budget. The 6430 Triple Quad offers the same combination of superior performance, exceptional reliability, and excellent overall cost-of-ownership for which Agilent is famous.

The 6430 Triple Quad has been engineered to achieve optimal quantitation of narrow UHPLC peaks. Reliable peak integration requires at least ten data points across a peak, mandating MS cycle times as low as 100 ms for a second-wide peak. Complex, multi-analyte assays require very short dwell times. The 6430 Triple Quad can keep up! It features extremely fast ion monitoring and polarity switching. The enhanced electronics in the 6430 Triple Quad enable 1 ms dwell times with no collision cell cross talk. Further, the introduction of dynamic MRM methods allows dynamic selection of MRM transitions during a method, based on retention time windows, to optimize instrument cycle time and maximize collection of high quality quantitative data. This allows hundreds of compounds to be analyzed in a single LC/MS run. Samples containing compounds with both positive and negative ion transitions require fast polarity switching – the 6430 Triple Quad can change polarity and begin acquiring data in just 30 ms. The improvement in polarity switching times is derived from a new, resistively coated capillary that reacts very quickly to voltage changes.

In addition to fast analysis capabilities, the 6430 Triple Quad is more sensitive than its predecessor – it has a standard second turbo pump in the Q3 region to enhance ion transmission by reducing chemical noise.