Varian 500-MS Ion Trap LC-MS System

System includes:

• Varian 500-MS Ion Trap Mass Spectrometer
• Solvent Tray
• Varian 460-LC AutoSampler
• Varian ProStar 335 DAD Diode Array Detector
• Varian 212-LC Chromatography Pump (x2)
• Necessary vacuum roughing pump(s)
• Windows PC with suitable software data (monitor not included)
• LC Starter Kit with tubing and fittings
• Minimum required cables for power and operation

LC/MS Performance and Productivity through Innovation

The Varian 500-MS LC ion trap is the instrument of choice for high-throughput LC/MS analysis where sensitivity, reliability, and productivity are essential.

The Varian 500-MS is a new and innovative system that provides a robust platform for demanding LC/MS/MS applications. The system sensitivity, mass resolution, and scan speed reflect the inherent advantages of the ion trap, while the new Enhanced Charge Capacity (ECC) extends the number of ions that can be stored. The results are greater sensitivity and reduced background noise for reliable quantitation.

By delivering excellent sensitivity over the entire mass range in full scan mode, and exceptional MS/MS and MSn capabilities, the Varian 500-MS quickly provides superior qualitative information, for even the most complex sample matrices. Unique sensitivity enhancements include SelecTemp, the temperature programmable API (Atmospheric Pressure Ionization), for the optimum analysis of thermally labile compounds. These innovations lead to the remarkable performance and capabilities of the Varian 500-MS LC ion trap.

State-of-the-art API interface

The Varian 500-MS delivers increased sensitivity and selectivity for all analytes. Even highly thermally labile compounds can be reliably analyzed, using Varian, Inc.’s patent pending temperature programmable SelecTemp  API interface. Maintaining sample integrity is no longer a concern.

SelecTemp’s programmable temperature control delivers optimum drying gas temperatures at every time point throughout a complex analysis. Additional SelecTemp API benefits include reduced interface contamination, improved throughput, simplified setup, and automatically recorded parameters for GLP purposes.

The rugged yet elegant design of the SelecTemp API and its unique capabilities will improve the performance of routine, high sample throughput applications reliably, consistently, and easily while increasing accuracy and productivity.

ECC, triple resonance, and the power of MSn

ECC ensures the reliable detection of trace amounts in the presence of high concentrations of coeluting compounds and heavy matrices. Patented triple resonance scanning allows scan speeds up to 15,000 Da/sec and preserves chromatographic spectral resolution. The fast scan speed is complemented by rapid ion polarity switching of 200 milliseconds to accommodate optimum detection of ion polarity for every analyte in the sample. Enhanced qualitative information is delivered by the 500-MS with MSn operation to n=10, expanding the spectral information content for structure elucidation.

Unequaled ownership advantages

The Varian 500-MS versatility and distinctive features allow easy adjustment to accommodate a wide variety of analytical requirements. The standard electrospray ionization source (ESI) of the 500-MS can easily be replaced with an optional Atmospheric Pressure ionization (APCI) source in less than a minute.

LC flow rates from microliters to milliliters can be used with the fully adjustable electrospray ion source and the vortex atmospheric pressure chemical ionization source. The novel design of the ion sources means the 500-MS requires less cleaning, leading to returns in up-time and productivity. The built in syringe pump, diverter valve, and Electronic Gas Control (EGC) provide ease-of-use benefits enhancing productivity even more. Clearly, the performance-driven Varian 500-MS delivers increased selectivity, sensitivity, and accuracy while reducing contamination and downtime. The resounding capabilities of the Varian 500-MS ultimately translate into value through exceptional results, unparalleled economy, and cost of ownership advantages second to none.