Agilent G9531A RapidFire 365 High-throughput Mass Spectrometry System

The RapidFire 365 High-throughput Mass Spectrometry System helps to eliminate bottlenecks in your drug discovery workflow and enhance the screening process of sample analyses. By feeding samples directly to the mass spectrometer, RapidFire technology enables the acceleration of drug discovery pipeline decisions.

The high-throughput mass spectrometry system consists of a proprietary sample purification and injection system that interfaces directly with the mass spectrometer. The RapidFire-MS system can simultaneously analyze multiple analytes in complex mixtures presented by biological samples and remove contaminants such as salts, buffers, detergents, proteins, microsomes, and subcellular material.

The RapidFire system facilitates the analysis of one 384-well plate in about 50 minutes or as many as ten 384-well plates (3840 individual samples) in a single instrument shift (8 hours). When you run an experiment continuously over a weekend, the system can run 63 plates (24192 individual samples). The throughput of the RapidFire system for label-free biologically-relevant data approaches that of optical technologies.

The system is equipped with one BenchBot sample handler and four plate stacks. The plate stacks enable the system to process 63 microplates in one batch. Three plate stacks serve as the input stacks, and each can accommodate 21 microplates. One plate stack is left empty to serve as the output stack. When all of the plates from one input stack is moved to the output stack, the original input stack becomes the output stack. In addition, the barcode scanner is capable of reading barcode labels on any side of the sample plates.