Waters Micromass Q-Tof Premier Mass Spectrometer

The next generation of Q-Tof technology

Introducing Waters Q-Tof Premier Mass Spectrometer, the next generation exact mass API/MALDI MS/MS platform for the Pharmaceutical, Biotechnology and Life Science industries. The Q-Tof Premier Mass Spectrometer, featuring T-Wave (Travelling Wave) technology, offers significant enhancements in mass measurement accuracy, dynamic range (pDRE), sensitivity (Enhanced Duty Cycle) and speed. If you want to quantify, identify, and characterize compounds from simple or complex mixtures, Waters Q-Tof Premier offers the finest blend of innovative analytical capabilities for results you’ll have the ultimate confidence in.

A new analytical paradigm: Ultra Performance Q-Tof LC/MS/MS

Waters Q-Tof Premier mass spectrometer is the first compact exact mass LC/MS/MS platform to incorporate ACQUITY Ultra Performance LC technology. The ACQUITY UPLC system marks an unparalleled breakthrough in separations science, with innovative technologies that enable significant improvements in performance for your application. So, if you need to characterize mixtures with the ultimate in resolution, sensitivity and speed or require a simple, easy-to-use, direct nanoflow solution (nanoACQUITY UPLC) with unparalleled retention time reproducibility, look no further than Ultra Performance Q-Tof LC/MS/MS.

The Premier Technology Platform

The Q-Tof Premier is a hybrid orthogonal acceleration Time-of-Flight (oa-ToF) mass spectrometer that enables automated exact mass measurement of precursor and fragment ions to yield the highest confidence in structural elucidation and databank search results.

The Q-Tof Premier is a high-performance platform for MS and MS/MS analyses incorporating:

• High sensitivity— High transmission efficiency of ZSpray source technology, T-Wave ion optics, T-Wave collision cell and oa-Tof transmission result in high sensitivity
• High resolution— Up to 17,500 FWHM with W-Optics
• High mass measurement capability— Routine exact mass measurement (3 ppm RMS) in MS and MS/MS with LockSpray and NanoLockSpray
• Enhanced speed— Faster TDC (4 GHZ) delivers acquisition speeds of up to 20 spectra per second—compatible with UPLC-based separations
• Dynamic Range Enhancement (pDRE)— Equipped with programmable DRE function, which enables quantitation and exact mass measurement over 4 orders of magnitude
• Enhanced Duty Cycle— Enables enhanced sensitivity over targeted m/z ranges for detection of modified components (e.g. in Precursor Ion Discovery)
• MALDI— Exchangeable vacuum MALDI source enabling large scale MALDI MS and MS/MS analyses—compatible with 96- and 384-spot target plates
• Resolving quadrupole— 4, 8 and 32k Da options
• m/z range— up to 100,000 in V-Optics
• Intelligent, automated MS/MS acquisition— Data Directed Analysis (DDA) and Precursor Ion Discovery
• Source options— LockSpray, NanoLockSpray, IonSABRE, APCI, ESCi and APPI
• Ergonomics— New industrial design, reduced instrument footprint

programmable Dynamic Range Enhancement (pDRE)

The full mass range spectra produced by the Q-Tof Premier enables a wide range of components, both known and unknown, to be detected from mixtures with high sensitivity. In the characterization of such components, they may be present in a wide range of concentrations. Programmable Dynamic Range Enhancement delivers up to 4 orders of magnitude for exact mass measurement and linear quantitative analysis of complex mixtures.